The reason it's so poisonous is because the skin is densely coated in alkaloid acid. The poison prevents its victims nerves from transmitting impulses leaving muscles in an active state of contraction, which can lead to heart failure.
The frog is estimated to have one milligram of poison, enough to kill 10,000 mice. Now that's a lot of mice. They're diet contains of many kinds of small insects like ants. The frog is the man source of the poison dart for the natives to hunt for their food.
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